Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.

Bracken, Colton J; Lim, Shion A; Solomon, Paige; Rettko, Nicholas J; Nguyen, Duy P; Zha, Beth Shoshana; Schaefer, Kaitlin; Byrnes, James R; Zhou, Jie; Lui, Irene; Liu, Jia; Pance, Katarina; Zhou, Xin X; Leung, Kevin K; Wells, James A

Bracken, Colton J; Lim, Shion A; Solomon, Paige; Rettko, Nicholas J; Nguyen, Duy P; Zha, Beth Shoshana; Schaefer, Kaitlin; Byrnes, James R; Zhou, Jie; Lui, Irene; Liu, Jia; Pance, Katarina; Zhou, Xin X; Leung, Kevin K; Wells, James A.

Afiliación

Bracken CJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Lim SA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Solomon P; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Rettko NJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Nguyen DP; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Zha BS; Department of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94158, USA.
Schaefer K; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Byrnes JR; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Zhou J; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Lui I; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Liu J; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Pance K; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Zhou XX; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Leung KK; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Wells JA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.

bioRxiv ; 2020 Aug 10.

Article en En | MEDLINE | ID: mdl-32817948

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: BioRxiv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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