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Silibinin-hydroxypropyl-ß-cyclodextrin (SLB-HP-ß-CD) complex prevents apoptosis in liver and kidney after hepatic ischemia-reperfusion injury.
Tsaroucha, Alexandra K; Korovesis, Georgios N; Valsami, Georgia; Lambropoulou, Maria; Kollaras, Vasileios; Anagnostopoulos, Constatinos; Kostomitsopoulos, Nikolaos; Zerbini, Eleni; Simopoulos, Constantinos.
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  • Tsaroucha AK; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece; 2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece; Department of Expe
  • Korovesis GN; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Valsami G; School of Health Sciences, Department of Pharmacy, National and Kapodistrian University of Athens, Greece.
  • Lambropoulou M; Laboratory of Histology-Embryology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Kollaras V; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Anagnostopoulos C; Laboratory of Biochemistry, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Kostomitsopoulos N; Department of Experimental Surgery, Bioresearch Foundation of the Academy of Athens, Athens, Greece.
  • Zerbini E; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
  • Simopoulos C; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece; Department of Experimental Surgery, Bioresearch Foundation of the Academy of Athens, Athens, Greece.
Food Chem Toxicol ; 145: 111731, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32891719
BACKGROUND: We investigated the protective effect of silibinin on rat liver and kidney after hepatic inschemia/reperfusion (I/R) injury. METHODS AND MATERIALS: Sixty three male Wistar-type rats (median age 13 weeks; average weight 314 g) were subjected to I/R injury of the liver. They were randomly divided into three groups: Sham (n = 7), Control (C, n = 28) and Silibinin (Si, n = 28). The last group received intravenously silibinin. The C and Si groups were each subdivided in four subgroups according to euthanasia times (i.e., 60, 120, 180, 240 min). We assessed expression of caspase-3 and TUNEL assay, and biochemical and histological parameters. RESULTS: At 240 min, expression of caspase-3 and TUNEL assay were statistically significantly lower in the Si compared to the C group for both liver and kidney. SGOT and SGPT were also statistically significantly lower in the Si than in the C group at all time points. Histological parameters of the liver were also improved in the Si group. CONCLUSION: Silibinin was found to exhibit a protective effect on liver and kidney after hepatic I/R injury. The present results are encouraging for further studies and future clinical application.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Daño por Reperfusión / 2-Hidroxipropil-beta-Ciclodextrina / Silibina / Riñón Límite: Animals / Humans / Male Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Daño por Reperfusión / 2-Hidroxipropil-beta-Ciclodextrina / Silibina / Riñón Límite: Animals / Humans / Male Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article