Uterine bleeding with hormone therapies in menopausal women: a systematic review.
Climacteric
; 23(6): 550-558, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32893694
ABSTRACT
Uterine bleeding is a common reason why women discontinue menopausal hormone therapy (HT). This systematic review compared bleeding profiles reported in studies for continuous-combined HT approved in North America and Europe for moderate to severe vasomotor symptoms in postmenopausal women with a uterus. Non-head-to-head studies showed that uterine bleeding varies by formulation and administration route, with oral having a better bleeding profile than transdermal formulations. Cumulative amenorrhea over a year ranged from 18 to 61% with oral HT and from 9 to 27% with transdermal HT, as reported for continuous-combined HT containing 17ß-estradiol (E2)/progesterone (P4) (56%), E2/norethisterone acetate (NETA) (49%), E2/drospirenone (45%), conjugated equine estrogens/medroxyprogesterone acetate (18-54%), ethinyl estradiol/NETA (31-61%), E2/levonorgestrel patch (16%), and E2/NETA patch (9-27%). Amenorrhea rates and the mean number of bleeding/spotting days improved over time. The oral E2/P4 combination was amongst those with lower bleeding rates and may be an appropriate alternative for millions of women seeking bioidentical HT and/or those who have bleeding concerns with other HT.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Progesterona
/
Hemorragia Uterina
/
Menopausia
/
Terapia de Reemplazo de Estrógeno
/
Estrógenos
Tipo de estudio:
Systematic_reviews
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Climacteric
Asunto de la revista:
GINECOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos