SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts.
J Assist Reprod Genet
; 37(11): 2657-2660, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32959144
ABSTRACT
PURPOSE:
To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts.METHODS:
Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research.RESULTS:
SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma.CONCLUSION:
Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oocitos
/
Blastocisto
/
Peptidil-Dipeptidasa A
/
Basigina
Límite:
Female
/
Humans
Idioma:
En
Revista:
J Assist Reprod Genet
Asunto de la revista:
GENETICA
/
MEDICINA REPRODUTIVA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Bélgica