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First report of t(5;11) KMT2A-MAML1 fusion in de novo infant acute lymphoblastic leukemia.
Tandon, Sneha; Shago, Mary; Davidson, Scott; Kanwar, Nisha; Fuligni, Fabio; Shlien, Adam; Whitlock, James; Villani, Anita; Abla, Oussama.
Afiliación
  • Tandon S; Division of Hematology and Oncology, University Hospital Southampton, United Kingdom. Electronic address: Sneha.tandon@uhs.nhs.uk.
  • Shago M; The Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Davidson S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Kanwar N; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Fuligni F; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Shlien A; The Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.
  • Whitlock J; Division of Pediatrics Hematology/Oncology, The Hospital for Sick Children; Department of Pediatrics, University of Toronto, Toronto, Canada.
  • Villani A; Division of Pediatrics Hematology/Oncology, The Hospital for Sick Children; Department of Pediatrics, University of Toronto, Toronto, Canada.
  • Abla O; Division of Pediatrics Hematology/Oncology, The Hospital for Sick Children; Department of Pediatrics, University of Toronto, Toronto, Canada.
Cancer Genet ; 248-249: 31-33, 2020 10.
Article en En | MEDLINE | ID: mdl-32992102
ABSTRACT
Infant acute lymphoblastic leukemia (ALL) comprises 2.5%-5% of pediatric ALL with inferior survival compared to older children. A majority of infants (80%) with ALL harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94 different partner genes have been identified to date. The common rearrangements include t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number of patients are needed to better understand its prognostic significance.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factores de Transcripción / Translocación Genética / Cromosomas Humanos Par 5 / Cromosomas Humanos Par 11 / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Proteínas de Fusión Oncogénica / N-Metiltransferasa de Histona-Lisina / Proteínas de Unión al ADN / Proteína de la Leucemia Mieloide-Linfoide Tipo de estudio: Prognostic_studies Límite: Humans / Infant / Male Idioma: En Revista: Cancer Genet Año: 2020 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factores de Transcripción / Translocación Genética / Cromosomas Humanos Par 5 / Cromosomas Humanos Par 11 / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Proteínas de Fusión Oncogénica / N-Metiltransferasa de Histona-Lisina / Proteínas de Unión al ADN / Proteína de la Leucemia Mieloide-Linfoide Tipo de estudio: Prognostic_studies Límite: Humans / Infant / Male Idioma: En Revista: Cancer Genet Año: 2020 Tipo del documento: Article