Moderate hypofractionated radiotherapy for post-operative treatment of prostate cancer: long-term outcome and pattern of toxicity.
Strahlenther Onkol
; 197(2): 133-140, 2021 Feb.
Article
en En
| MEDLINE
| ID: mdl-33006025
ABSTRACT
OBJECTIVE:
Postoperative radiotherapy (RT) is an established treatment for prostate cancer (PC). Though hypofractionation is commonly used for radical treatments, open issues still remain in the postoperative setting due to the lack of long-term data. Aim of this study was to evaluate long-term results of postoperative moderately hypofractionated RT (MHRT).METHODS:
We conducted a retrospective analysis including PC patients treated with prostatectomy and postoperative MHRT delivered with volumetric modulated arc therapy (VMAT). Endpoints of the analysis included biochemical relapse-free survival (BRFS), distant metastases free-survival (DMFS), overall survival (OS), and pattern of acute and late toxicity.RESULTS:
181 patients were included. Pathological stage was classified as pT3a in 33.6% and pT3b in 30%. Median PSA value before RT was 0.23â¯ng/ml and median RT total dose was 70â¯Gy (65-74.2â¯Gy) in 25/28 fractions. With a median follow-up of 54.5 months, rates of BRFS at 3 and 5 years were 80.7 and 72.3%. ISUP grade group (HR 1.44, pâ¯= 0.015), pathological T stage (HR 2.03; pâ¯= 0.009), and pre-RT PSA >0.2â¯ng/ml (HR 2.64; pâ¯= 0.015) were correlated with BRFS. Three and 5year DMFS were 87.4 and 80.8%. ISUP grade group (HR 1.50; pâ¯= 0.011) and pre-RT PSA (HR 5.34; pâ¯= 0.001) were correlated with DMFS. Five (2.7%) and 3 (1.6%) patients reported late grade 3 GU and GI toxicity, respectively.CONCLUSION:
Our results confirm the long-term safety and efficacy of postoperative MHRT for PC. ADVANCES IN KNOWLEDGE The present paper demonstrates the long-term safety and efficacy of MHRT for postoperative prostate cancer. Reduction of treatment time in long-course radiotherapy has advantages in terms of both patients' quality of life and departmental organization.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Radioterapia de Intensidad Modulada
/
Hipofraccionamiento de la Dosis de Radiación
Tipo de estudio:
Observational_studies
Límite:
Aged
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Aged80
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Strahlenther Onkol
Asunto de la revista:
NEOPLASIAS
/
RADIOTERAPIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia