Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.

Anbar, Hanan S; El-Gamal, Randa; Ullah, Saif; Zaraei, Seyed-Omar; Al-Rashida, Mariya; Zaib, Sumera; Pelletier, Julie; Sévigny, Jean; Iqbal, Jamshed; El-Gamal, Mohammed I

Anbar, Hanan S; El-Gamal, Randa; Ullah, Saif; Zaraei, Seyed-Omar; Al-Rashida, Mariya; Zaib, Sumera; Pelletier, Julie; Sévigny, Jean; Iqbal, Jamshed; El-Gamal, Mohammed I.

Afiliación

Anbar HS; Department of Clinical Pharmacy and Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai 19099, United Arab Emirates.
El-Gamal R; Department of Medical Biochemistry, Faculty of Medicine, University of Mansoura, Mansoura 35516, Egypt.
Ullah S; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Zaraei SO; Center for Biomaterials, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea; Department of Biomolecular Science, Korea University of Science and Technology, 113 Gwahangno, Yuseong-gu, Daejeon 305-333, Republic of Korea.
Al-Rashida M; Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore, Pakistan.
Zaib S; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Pelletier J; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC G1V 4G2, Canada.
Sévigny J; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC G1V 4G2, Canada; Département de microbiologie-infectiologie et d'immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan. Electronic address: drjamshed@cuiatd.edu.pk.
El-Gamal MI; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mans

Bioorg Chem ; 104: 104305, 2020 11.

Article en En | MEDLINE | ID: mdl-33017718

Asunto(s)

Antineoplásicos/farmacología; Benzofuranos/farmacología; Inhibidores Enzimáticos/farmacología; Ácidos Sulfónicos/farmacología; Tiofenos/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Benzofuranos/síntesis química; Benzofuranos/química; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Humanos; Simulación del Acoplamiento Molecular; Estructura Molecular; Hidrolasas Diéster Fosfóricas/metabolismo; Pirofosfatasas/antagonistas & inhibidores; Pirofosfatasas/metabolismo; Relación Estructura-Actividad; Ácidos Sulfónicos/síntesis química; Ácidos Sulfónicos/química; Tiofenos/síntesis química; Tiofenos/química; Células Tumorales Cultivadas

Palabras clave

Antiproliferative activity; Benzofuran sulfonates and sulfamates; Benzothiophene sulfonates and sulfamates; Enzyme inhibition assay; Human ecto-nucleotide pyrophosphatases/phosphodiesterase-1 and -3; In-silico study

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácidos Sulfónicos / Tiofenos / Benzofuranos / Inhibidores Enzimáticos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article País de afiliación: Emiratos Árabes Unidos

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