Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells.
FEBS Lett
; 221(1): 18-22, 1987 Aug 31.
Article
en En
| MEDLINE
| ID: mdl-3305075
ABSTRACT
Conditioned medium from human monocytes contains a partially characterized hepatocyte-stimulating factor that simultaneously elevates the mRNA levels of the acute-phase protein beta-fibrinogen and decreases albumin mRNA in rat hepatoma cells. We demonstrate that recombinant human B-cell stimulatory factor 2, which is identical to interferon-beta 2/26 kDa protein and interleukin-HP1, exhibits the same activity as hepatocyte-stimulating factor. Furthermore, a specific antibody against B-cell stimulatory factor 2 was able to inhibit hepatocyte-stimulating factor in conditioned medium from human monocytes. Our data show that hepatocyte-stimulating factor and B-cell stimulatory factor 2 are functionally and immunologically related proteins.
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Bases de datos:
MEDLINE
Asunto principal:
Fibrinógeno
/
ARN Mensajero
/
Linfocinas
/
Albúminas
/
Neoplasias Hepáticas Experimentales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1987
Tipo del documento:
Article