Collective cancer cell invasion requires RNA accumulation at the invasive front.

Chrisafis, George; Wang, Tianhong; Moissoglu, Konstadinos; Gasparski, Alexander N; Ng, Yeap; Weigert, Roberto; Lockett, Stephen J; Mili, Stavroula

Chrisafis, George; Wang, Tianhong; Moissoglu, Konstadinos; Gasparski, Alexander N; Ng, Yeap; Weigert, Roberto; Lockett, Stephen J; Mili, Stavroula.

Afiliación

Chrisafis G; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Wang T; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Moissoglu K; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Gasparski AN; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Ng Y; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Weigert R; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. for the National Cancer Institute, NIH, Frederick, MD 21702.
Mili S; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892; voula.mili@nih.gov.

Proc Natl Acad Sci U S A ; 117(44): 27423-27434, 2020 11 03.

Article en En | MEDLINE | ID: mdl-33060293

Asunto(s)

Movimiento Celular/genética; Invasividad Neoplásica/genética; Neoplasias/patología; ARN Mensajero/metabolismo; Proteína de la Poliposis Adenomatosa del Colon/genética; Animales; Línea Celular Tumoral; Progresión de la Enfermedad; Femenino; Células HeLa; Humanos; Hibridación Fluorescente in Situ; Microscopía Intravital; Ratones; Microscopía Confocal; Invasividad Neoplásica/prevención & control; Neoplasias/genética; Proteínas Oncogénicas/genética; ARN Interferente Pequeño; Esferoides Celulares; Ensayos Antitumor por Modelo de Xenoinjerto; Proteínas de Unión al GTP rab/genética

Palabras clave

NET1; RAB13; RNA localization; antisense oligo; collective invasion

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN Mensajero / Movimiento Celular / Invasividad Neoplásica / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

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