High temperature promotes amyloid ß-protein production and Î³-secretase complex formation via Hsp90.

Noorani, Arshad Ali; Yamashita, Hitoshi; Gao, Yuan; Islam, Sadequl; Sun, Yang; Nakamura, Tomohisa; Enomoto, Hiroyuki; Zou, Kun; Michikawa, Makoto

Noorani, Arshad Ali; Yamashita, Hitoshi; Gao, Yuan; Islam, Sadequl; Sun, Yang; Nakamura, Tomohisa; Enomoto, Hiroyuki; Zou, Kun; Michikawa, Makoto.

Afiliación

Noorani AA; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Yamashita H; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Gao Y; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Islam S; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Sun Y; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Nakamura T; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Enomoto H; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Zou K; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: kunzou@med.nagoya-cu.ac.jp.
Michikawa M; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: michi@med.nagoya-cu.ac.jp.

J Biol Chem ; 295(52): 18010-18022, 2020 12 25.

Article en En | MEDLINE | ID: mdl-33067321

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/análisis; Precursor de Proteína beta-Amiloide/metabolismo; Membrana Celular/metabolismo; Proteínas HSP90 de Choque Térmico/metabolismo; Calor; Secretasas de la Proteína Precursora del Amiloide/genética; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Animales; Femenino; Proteínas HSP90 de Choque Térmico/genética; Humanos; Ratones; Ratones Endogámicos C57BL; Unión Proteica

Palabras clave

Alzheimer disease; Alzheimer's disease; amyloid ß-protein; amyloid-beta (AB); gamma-secretase; heat shock protein 90 (Hsp90); presenilin; temperature; Î³-secretase

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Membrana Celular / Péptidos beta-Amiloides / Precursor de Proteína beta-Amiloide / Proteínas HSP90 de Choque Térmico / Secretasas de la Proteína Precursora del Amiloide / Calor Límite: Animals / Female / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google