Factor H-related protein 1: a complement regulatory protein and guardian of necrotic-type surfaces.
Br J Pharmacol
; 178(14): 2823-2831, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33085794
ABSTRACT
Factor H-related protein 1 (FHR-1) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, CFHR1 on human chromosome 1, is involved in diseases such as age-related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome, indicating an important role for FHR-1 in human health. Recent research data demonstrate that FHR-1 levels increase in IgA nephropathy and anti-neutrophilic cytoplasmic autoantibodies (ANCA) vasculitis and that FHR-1 induces strong inflammation in monocytes on necrotic-type surfaces, suggesting a complement-independent role. These new results increase our knowledge about the role of this complement protein in pathology and provide a new therapeutic target, particularly in the context of inflammatory diseases induced by necrosis. This review summarizes current knowledge about FHR-1 and discusses its role in complement reactions and inflammation. LINKED ARTICLES This article is part of a themed issue on Canonical and non-canonical functions of the complement system in health and disease. To view the other articles in this section visit http//onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas del Sistema Complemento
/
Factor H de Complemento
Límite:
Humans
Idioma:
En
Revista:
Br J Pharmacol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania