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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Miorin, Lisa; Kehrer, Thomas; Sanchez-Aparicio, Maria Teresa; Zhang, Ke; Cohen, Phillip; Patel, Roosheel S; Cupic, Anastasija; Makio, Tadashi; Mei, Menghan; Moreno, Elena; Danziger, Oded; White, Kris M; Rathnasinghe, Raveen; Uccellini, Melissa; Gao, Shengyan; Aydillo, Teresa; Mena, Ignacio; Yin, Xin; Martin-Sancho, Laura; Krogan, Nevan J; Chanda, Sumit K; Schotsaert, Michael; Wozniak, Richard W; Ren, Yi; Rosenberg, Brad R; Fontoura, Beatriz M A; García-Sastre, Adolfo.
Afiliación
  • Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; lisa.miorin@mssm.edu adolfo.garcia-sastre@mssm.edu.
  • Kehrer T; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Zhang K; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Cohen P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Patel RS; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Cupic A; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Makio T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Mei M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Danziger O; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • White KM; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
  • Rathnasinghe R; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
  • Uccellini M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Gao S; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Aydillo T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Mena I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Yin X; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Martin-Sancho L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Krogan NJ; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Chanda SK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Schotsaert M; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Wozniak RW; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Ren Y; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Rosenberg BR; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Fontoura BMA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • García-Sastre A; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Proc Natl Acad Sci U S A ; 117(45): 28344-28354, 2020 11 10.
Article en En | MEDLINE | ID: mdl-33097660
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Virales / Interferones / Poro Nuclear / Proteínas de Complejo Poro Nuclear / Factor de Transcripción STAT1 / Factor de Transcripción STAT2 / COVID-19 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Virales / Interferones / Poro Nuclear / Proteínas de Complejo Poro Nuclear / Factor de Transcripción STAT1 / Factor de Transcripción STAT2 / COVID-19 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article