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Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial.
Bratlie, Marianne; Hagen, Ingrid V; Helland, Anita; Erchinger, Friedemann; Midttun, Øivind; Ueland, Per Magne; Rosenlund, Grethe; Sveier, Harald; Mellgren, Gunnar; Hausken, Trygve; Gudbrandsen, Oddrun Anita.
Afiliación
  • Bratlie M; Dietary Protein Research Group, Department of Clinical Medicine, Haukeland University Hospital, University of Bergen, 5021, Bergen, Norway.
  • Hagen IV; Dietary Protein Research Group, Department of Clinical Medicine, Haukeland University Hospital, University of Bergen, 5021, Bergen, Norway.
  • Helland A; Dietary Protein Research Group, Department of Clinical Medicine, Haukeland University Hospital, University of Bergen, 5021, Bergen, Norway.
  • Erchinger F; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  • Midttun Ø; Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway.
  • Ueland PM; Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway.
  • Rosenlund G; Skretting Aquaculture Research Centre AS, P.O. Box 48, 4001, Stavanger, Norway.
  • Sveier H; Lerøy Seafood Group ASA, P.O. Box 7600, 5020, Bergen, Norway.
  • Mellgren G; Mohn Nutrition Research Laboratory, Department of Clinical Science, Haukeland University Hospital, University of Bergen, 5021, Bergen, Norway.
  • Hausken T; Hormone Laboratory, Haukeland University Hospital, 5021, Bergen, Norway.
  • Gudbrandsen OA; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Eur J Nutr ; 60(4): 2231-2248, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33108521
PURPOSE: To explore whether high intake of cod or salmon would affect gut microbiota profile, faecal output and serum concentrations of lipids and bile acids. METHODS: Seventy-six adults with overweight/obesity with no reported gastrointestinal disease were randomly assigned to consume 750 g/week of either cod or salmon, or to avoid fish intake (Control group) for 8 weeks. Fifteen participants from each group were randomly selected for 72 h faeces collection at baseline and end point for gut microbiota profile analyses using 54 bacterial DNA probes. Food intake was registered, and fasting serum and morning urine were collected at baseline and end point. RESULTS: Sixty-five participants were included in serum and urine analyses, and gut microbiota profile was analysed for 33 participants. Principal component analysis of gut microbiota showed an almost complete separation of the Salmon group from the Control group, with lower counts for bacteria in the Bacteroidetes phylum and the Clostridiales order of the Firmicutes phyla, and higher counts for bacteria in the Selenomonadales order of the Firmicutes phylum. The Cod group showed greater similarity to the Salmon group than to the Control group. Intake of fibres, proteins, fats and carbohydrates, faecal daily mass and output of fat, cholesterol and total bile acids, and serum concentrations of cholesterol, triacylglycerols, non-esterified fatty acids and total bile acids were not altered in the experimental groups. CONCLUSION: A high intake of cod or salmon fillet modulated gut microbiota but did not affect faecal output or serum concentrations of lipids and total bile acids. CLINICAL TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov as NCT02350595.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal Tipo de estudio: Clinical_trials Límite: Adult / Animals / Humans Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Noruega

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal Tipo de estudio: Clinical_trials Límite: Adult / Animals / Humans Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Noruega