Targeted potent antimicrobial benzochromene-based analogues: Synthesis, computational studies, and inhibitory effect against 14&#945;-Demethylase and DNA Gyrase.

Fouda, Ahmed M; Hassan, Ahmed H; Eliwa, Essam M; Ahmed, Hany E A; Al-Dies, Al-Anood M; Omar, Abdelsattar M; Nassar, Hesham S; Halawa, Ahmed H; Aljuhani, Naif; El-Agrody, Ahmed M

Targeted potent antimicrobial benzochromene-based analogues: Synthesis, computational studies, and inhibitory effect against 14α-Demethylase and DNA Gyrase.

Fouda, Ahmed M; Hassan, Ahmed H; Eliwa, Essam M; Ahmed, Hany E A; Al-Dies, Al-Anood M; Omar, Abdelsattar M; Nassar, Hesham S; Halawa, Ahmed H; Aljuhani, Naif; El-Agrody, Ahmed M.

Afiliación

Fouda AM; Chemistry Department, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia.
Hassan AH; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt; Chemistry Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia.
Eliwa EM; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Ahmed HEA; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Al-Dies AM; Biology and Chemistry Department, Al-Qunfudah University College, Umm Al-Qura University, Al-Qunfudah 1109, Saudi Arabia.
Omar AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Nassar HS; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt; Chemistry Department, Faculty of Science and Art, Al-Baha University, Al-Baha 1988, Saudi Arabia.
Halawa AH; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Aljuhani N; Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia.
El-Agrody AM; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt. Electronic address: elagrody_am@azhar.edu.eg.

Bioorg Chem ; 105: 104387, 2020 12.

Article en En | MEDLINE | ID: mdl-33130344

Asunto(s)

Inhibidores de 14 alfa Desmetilasa/farmacología; Antibacterianos/farmacología; Antifúngicos/farmacología; Benzopiranos/farmacología; Inhibidores de Topoisomerasa II/farmacología; Inhibidores de 14 alfa Desmetilasa/síntesis química; Inhibidores de 14 alfa Desmetilasa/química; Antibacterianos/síntesis química; Antibacterianos/química; Antifúngicos/síntesis química; Antifúngicos/química; Aspergillus/efectos de los fármacos; Benzopiranos/síntesis química; Benzopiranos/química; Candida albicans/efectos de los fármacos; Girasa de ADN/metabolismo; Relación Dosis-Respuesta a Droga; Bacterias Grampositivas/efectos de los fármacos; Pruebas de Sensibilidad Microbiana; Simulación del Acoplamiento Molecular; Estructura Molecular; Esterol 14-Desmetilasa/metabolismo; Relación Estructura-Actividad; Inhibidores de Topoisomerasa II/síntesis química; Inhibidores de Topoisomerasa II/química

Palabras clave

14α-Demethylase; ADMET properties; Antimicrobial activities; DNA Gyrase; Molecular modeling; SAR; Triazolopyrimidine

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Benzopiranos / Inhibidores de 14 alfa Desmetilasa / Inhibidores de Topoisomerasa II / Antibacterianos / Antifúngicos Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article País de afiliación: Arabia Saudita

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