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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.
Zhang, Yunxiao; Lu, Wan-Jin; Bulkley, David P; Liang, Jiahao; Ralko, Arthur; Han, Shuo; Roberts, Kelsey J; Li, Anping; Cho, Wonhwa; Cheng, Yifan; Manglik, Aashish; Beachy, Philip A.
Afiliación
  • Zhang Y; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
  • Lu WJ; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
  • Bulkley DP; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
  • Liang J; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Ralko A; Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607.
  • Han S; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
  • Roberts KJ; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
  • Li A; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
  • Cho W; Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607.
  • Cheng Y; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
  • Manglik A; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158.
  • Beachy PA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; aashish.manglik@ucsf.edu pbeachy@stanford.edu.
Proc Natl Acad Sci U S A ; 117(46): 28838-28846, 2020 11 17.
Article en En | MEDLINE | ID: mdl-33139559
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor Patched-1 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor Patched-1 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article