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Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.
Cyrta, Joanna; Augspach, Anke; De Filippo, Maria Rosaria; Prandi, Davide; Thienger, Phillip; Benelli, Matteo; Cooley, Victoria; Bareja, Rohan; Wilkes, David; Chae, Sung-Suk; Cavaliere, Paola; Dephoure, Noah; Uldry, Anne-Christine; Lagache, Sophie Braga; Roma, Luca; Cohen, Sandra; Jaquet, Muriel; Brandt, Laura P; Alshalalfa, Mohammed; Puca, Loredana; Sboner, Andrea; Feng, Felix; Wang, Shangqian; Beltran, Himisha; Lotan, Tamara; Spahn, Martin; Kruithof-de Julio, Marianna; Chen, Yu; Ballman, Karla V; Demichelis, Francesca; Piscuoglio, Salvatore; Rubin, Mark A.
Afiliación
  • Cyrta J; Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland.
  • Augspach A; The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • De Filippo MR; Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland.
  • Prandi D; Department for BioMedical Research, Urology Research Laboratory, University of Bern, 3008, Bern, Switzerland.
  • Thienger P; Institute of Pathology and Medical Genetics, University Hospital Basel, University of Basel, 4051, Basel, Switzerland.
  • Benelli M; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38122, Trento, Italy.
  • Cooley V; Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland.
  • Bareja R; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38122, Trento, Italy.
  • Wilkes D; Bioinformatics Unit, Hospital of Prato, 59100, Prato, Italy.
  • Chae SS; Department of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Cavaliere P; The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Dephoure N; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Uldry AC; The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Lagache SB; Department of Laboratory Medicine and Pathology, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Roma L; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Cohen S; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Jaquet M; Department of Biochemistry, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Brandt LP; Proteomics Mass Spectrometry Core Facility, University of Bern, 3010, Bern, Switzerland.
  • Alshalalfa M; Proteomics Mass Spectrometry Core Facility, University of Bern, 3010, Bern, Switzerland.
  • Puca L; Institute of Pathology and Medical Genetics, University Hospital Basel, University of Basel, 4051, Basel, Switzerland.
  • Sboner A; Department of Laboratory Medicine and Pathology, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Feng F; Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland.
  • Wang S; Department for BioMedical Research, University of Bern, 3008, Bern, Switzerland.
  • Beltran H; Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA.
  • Lotan T; Department of Medicine, Division of Medical Oncology, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Spahn M; The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Kruithof-de Julio M; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Chen Y; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.
  • Ballman KV; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.
  • Demichelis F; Proteomics Mass Spectrometry Core Facility, University of Bern, 3010, Bern, Switzerland.
  • Piscuoglio S; Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Rubin MA; Department of Medicine, Division of Medical Oncology, Weill Cornell Medicine, New York, NY, 10021, USA.
Nat Commun ; 11(1): 5549, 2020 11 03.
Article en En | MEDLINE | ID: mdl-33144576
ABSTRACT
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10-20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Factores de Transcripción / Proteínas Cromosómicas no Histona / Linaje de la Célula / Plasticidad de la Célula Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Factores de Transcripción / Proteínas Cromosómicas no Histona / Linaje de la Célula / Plasticidad de la Célula Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Suiza