Crosstalk between oncogenic MYC and noncoding RNAs in cancer.
Semin Cancer Biol
; 75: 62-71, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-33160022
ABSTRACT
The MYC family oncoproteins are deregulated in more than 50 % of human cancers through a variety of mechanisms, such as gene amplification or translocation, super-enhancer activation, aberrant upstream signaling, and altered protein stability. As one of the major drivers in tumorigenesis, MYC regulates the expression of a large number of noncoding genes involved in multiple oncogenic processes. Noncoding RNAs, including miRNA, lncRNA, circRNA, rRNA and tRNA, are also deeply involved in the oncogenic MYC network by functioning as MYC regulators/effectors. In this review, we summarize representative studies depicting the crosstalk between oncogenic MYC and noncoding RNAs in carcinogenesis with the aim of providing potential implications for both basic science and clinical applications.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
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Regulación Neoplásica de la Expresión Génica
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Amplificación de Genes
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Proteínas Proto-Oncogénicas c-myc
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ARN Largo no Codificante
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Semin Cancer Biol
Asunto de la revista:
NEOPLASIAS
Año:
2021
Tipo del documento:
Article