The nucleocapsid protein of zoonotic betacoronaviruses is an attractive target for antiviral drug discovery.
Life Sci
; 282: 118754, 2021 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-33189817
ABSTRACT
Betacoronaviruses are in one genera of coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), etc. These viruses threaten public health and cause dramatic economic losses. The nucleocapsid (N) protein is a structural protein of betacoronaviruses with multiple functions such as forming viral capsids with viral RNA, interacting with viral membrane protein to form the virus core with RNA, binding to several cellular kinases for signal transductions, etc. In this review, we highlighted the potential of the N protein as a suitable antiviral target from different perspectives, including structure, functions, and antiviral strategies for combatting betacoronaviruses.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Infecciones por Coronavirus
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Descubrimiento de Drogas
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Betacoronavirus
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Proteínas de la Nucleocápside de Coronavirus
Límite:
Animals
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Humans
Idioma:
En
Revista:
Life Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos