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Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil.
Zucchi, José William; Franco, Estefânia Aparecida Thomé; Schreck, Thomas; Castro E Silva, Maria Helena; Migliorini, Sandro Rogerio Dos Santos; Garcia, Thaís; Mota, Gustavo Augusto Ferreira; de Morais, Bruna Evelyn Bueno; Machado, Luiz Henrique Soares; Batista, Ana Natália Ribeiro; de Paiva, Sergio Alberto Rupp; de Godoy, Irma; Tanni, Suzana Erico.
Afiliación
  • Zucchi JW; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • Franco EAT; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • Schreck T; Ostbayerische Technische Hochschule Regensburg (OTH Regensburg), Faculty of Business Studies, Regensburg, German.
  • Castro E Silva MH; Pulmonology Division of Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Migliorini SRDS; Pulmonology Division of Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Garcia T; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • Mota GAF; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • de Morais BEB; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • Machado LHS; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • Batista ANR; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • de Paiva SAR; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • de Godoy I; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
  • Tanni SE; Pulmonology Division of Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
Int J Chron Obstruct Pulmon Dis ; 15: 2847-2856, 2020.
Article en En | MEDLINE | ID: mdl-33192058
Background: Chronic obstructive pulmonary disease (COPD) has a functional definition. However, differences in clinical characteristics and systemic manifestations make COPD a heterogeneous disease and some manifestations have been associated with different risks of acute exacerbations, hospitalizations, and death. Objective: Therefore, the objective of the study was to evaluate possible clinical clusters in COPD at two study centers in Brazil and identify the associated exacerbation and mortality rate during 1 year of follow-up. Methods: We included patients with COPD and all underwent an evaluation composed of the Charlson Index, body mass index (BMI), current pharmacological treatment, smoking history (packs-year), history of exacerbations/hospitalizations in the last year, spirometry, six-minute walking test (6MWT), quality of life questionnaires, dyspnea, and hospital anxiety and depression scale. Blood samples were also collected for measurements of C-reactive protein (CRP), blood gases, laboratory analysis, and blood count. For the construction of the clusters, 13 continuous variables of clinical importance were considered: hematocrit, CRP, triglycerides, low density lipoprotein, absolute number of peripheral eosinophils, age, pulse oximetry, BMI, forced expiratory volume in the first second, dyspnea, 6MWD, total score of the Saint George Respiratory Questionnaire and packs-year of smoking. We used the Ward and K-means methods and determined the best silhouette value to identify similarities of individuals within the cluster (cohesion) in relation to the other clusters (separation). The number of clusters was determined by the heterogeneity values of the cluster, which in this case was determined as four clusters. Results: We evaluated 301 COPD patients and identified four different groups of COPD patients. The first cluster (203 patients) was characterized by fewer symptoms and lower functional severity of the disease, the second cluster by higher values of peripheral eosinophils, the third cluster by more systemic inflammation and the fourth cluster by greater obstructive severity and worse gas exchange. Cluster 2 had an average of 959±3 peripheral eosinophils, cluster 3 had a higher prevalence of nutritional depletion (46.1%), and cluster 4 had a higher BODE index. Regarding the associated comorbidities, we found that only obstructive sleep apnea syndrome and pulmonary thromboembolism were more prevalent in cluster 4. Almost 50% of all patients presented an exacerbation during 1 year of follow-up. However, it was higher in cluster 4, with 65% of all patients having at least one exacerbation. The mortality rate was statistically higher in cluster 4, with 26.9%, vs 9.6% in cluster 1. Conclusion: We could identify four clinical different clusters in these COPD populations, that were related to different clinical manifestations, comorbidities, exacerbation, and mortality rate. We also identified a specific cluster with higher values of peripheral eosinophils.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Calidad de Vida / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Año: 2020 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Calidad de Vida / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Año: 2020 Tipo del documento: Article País de afiliación: Brasil