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Boronate probe-based hydrogen peroxide detection with AlGaN/GaN HEMT sensor.
Mahaboob, Isra; Reinertsen, Roger J; McEwen, Benjamin; Hogan, Kasey; Rocco, Emma; Melendez, J Andres; Cady, Nathaniel C; Shahedipour-Sandvik, F.
Afiliación
  • Mahaboob I; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Reinertsen RJ; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • McEwen B; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Hogan K; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Rocco E; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Melendez JA; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Cady NC; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
  • Shahedipour-Sandvik F; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.
Exp Biol Med (Maywood) ; 246(5): 523-528, 2021 03.
Article en En | MEDLINE | ID: mdl-33203229
The results from this study demonstrate the potential of an AlGaN/GaN high electron mobility transistor sensor for the detection of reactive and transient biological molecules such as hydrogen peroxide. A boronate-based fluorescent probe was used with this device to detect the presence of micromolar levels of hydrogen peroxide typically associated with intracellular processes. The real-time electrical response of the high electron mobility transistor sensor showed a gradual decrease in the two-dimensional electron gas current as the reaction proceeded over time. A corresponding increase in the emission intensity was measured from the fluorescent probe with the progression of the reaction. The fluorescence from the boronate probe was used as an indicator to confirm the detection of hydrogen peroxide. These results demonstrate the dynamic measurement capability of AlGaN/GaN high electron mobility transistor sensors in monitoring real-time reactions of reactive oxygen species such as hydrogen peroxide.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transistores Electrónicos / Ácidos Borónicos / Técnicas Biosensibles / Sondas Moleculares / Compuestos de Aluminio / Electrones / Galio / Peróxido de Hidrógeno Tipo de estudio: Diagnostic_studies Idioma: En Revista: Exp Biol Med (Maywood) Asunto de la revista: BIOLOGIA / FISIOLOGIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transistores Electrónicos / Ácidos Borónicos / Técnicas Biosensibles / Sondas Moleculares / Compuestos de Aluminio / Electrones / Galio / Peróxido de Hidrógeno Tipo de estudio: Diagnostic_studies Idioma: En Revista: Exp Biol Med (Maywood) Asunto de la revista: BIOLOGIA / FISIOLOGIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos