Improved stenosis outcome in stroke-free sickle cell anemia children after transplantation compared to chronic transfusion.
Br J Haematol
; 193(1): 188-193, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33216975
ABSTRACT
We report here the 3-year stenosis outcome in 60 stroke-free children with sickle cell anaemia (SCA) and an abnormal transcranial Doppler history, enrolled in the DREPAGREFFE trial, which compared stem cell transplantation (SCT) with standard-care (chronic transfusion for 1-year minimum). Twenty-eight patients with matched sibling donors were transplanted, while 32 remained on standard-care. Stenosis scores were calculated after performing cerebral/cervical 3D time-of-flight magnetic resonance angiography. Fourteen patients had stenosis at enrollment, but only five SCT versus 10 standard-care patients still had stenosis at 3 years. Stenosis scores remained stable on standard-care, but significantly improved after SCT (P = 0·006). No patient developed stenosis after SCT, while two on standard-care did, indicating better stenosis prevention and improved outcome after SCT.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transfusión Sanguínea
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Encéfalo
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Trasplante de Células Madre Hematopoyéticas
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Constricción Patológica
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Anemia de Células Falciformes
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Humans
Idioma:
En
Revista:
Br J Haematol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia