Host-directed editing of the SARS-CoV-2 genome.
Biochem Biophys Res Commun
; 538: 35-39, 2021 01 29.
Article
en En
| MEDLINE
| ID: mdl-33234239
ABSTRACT
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Adenosina Desaminasa
/
Proteínas de Unión al ARN
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Genoma Viral
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Interacciones Huésped-Patógeno
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Desaminasas APOBEC
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Edición Génica
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SARS-CoV-2
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COVID-19
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2021
Tipo del documento:
Article