Heparin-Induced Thrombocytopenia: A Focus on Thrombosis.
Arterioscler Thromb Vasc Biol
; 41(1): 141-152, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-33267665
ABSTRACT
Heparin-induced thrombocytopenia is an immune-mediated disorder caused by antibodies that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and unpredictable feature of this syndrome. Despite optimal management, disease morbidity and mortality from thrombosis remain high. The hypercoagulable state in heparin-induced thrombocytopenia is biologically distinct from other thrombophilic disorders in that clinical complications are directly attributable to circulating ultra-large immune complexes. In some individuals, ultra-large immune complexes elicit unchecked cellular procoagulant responses that culminate in thrombosis. To date, the clinical and biologic risk factors associated with thrombotic risk in heparin-induced thrombocytopenia remain elusive. This review will summarize our current understanding of thrombosis in heparin-induced thrombocytopenia with attention to its clinical features, cellular mechanisms, and its management.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trombocitopenia
/
Trombosis
/
Coagulación Sanguínea
/
Factor Plaquetario 4
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Heparina
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Anticuerpos
/
Anticoagulantes
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Asunto de la revista:
ANGIOLOGIA
Año:
2021
Tipo del documento:
Article