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Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.

Rodda, Lauren B; Netland, Jason; Shehata, Laila; Pruner, Kurt B; Morawski, Peter A; Thouvenel, Christopher D; Takehara, Kennidy K; Eggenberger, Julie; Hemann, Emily A; Waterman, Hayley R; Fahning, Mitchell L; Chen, Yu; Hale, Malika; Rathe, Jennifer; Stokes, Caleb; Wrenn, Samuel; Fiala, Brooke; Carter, Lauren; Hamerman, Jessica A; King, Neil P; Gale, Michael; Campbell, Daniel J; Rawlings, David J; Pepper, Marion.
Cell; 2020 Nov 23.
Artículo en Inglés | MEDLINE | ID: mdl-33296701
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.