A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants.
Acta Med Okayama
; 74(6): 557-562, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-33361878
ABSTRACT
A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
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Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
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Adenocarcinoma
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Deficiencia de Dihidropirimidina Deshidrogenasa
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Fluorouracilo
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Antimetabolitos Antineoplásicos
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Med Okayama
Año:
2020
Tipo del documento:
Article