<i>N</i>-Phenyl-6-Chloro-4-Hydroxy-2-Quinolone-3-CarboxAmides: Molecular Docking, Synthesis, and Biological Investigation as Anticancer Agents.

Sabbah, Dima A; Haroon, Rawan A; Bardaweel, Sanaa K; Hajjo, Rima; Sweidan, Kamal

N-Phenyl-6-Chloro-4-Hydroxy-2-Quinolone-3-CarboxAmides: Molecular Docking, Synthesis, and Biological Investigation as Anticancer Agents.

Sabbah, Dima A; Haroon, Rawan A; Bardaweel, Sanaa K; Hajjo, Rima; Sweidan, Kamal.

Afiliación

Sabbah DA; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Haroon RA; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Bardaweel SK; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan.
Hajjo R; Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Sweidan K; Department of Chemistry, The University of Jordan, Amman 11942, Jordan.

Molecules ; 26(1)2020 Dec 25.

Article en En | MEDLINE | ID: mdl-33375766

Asunto(s)

Amidas/química; Neoplasias/tratamiento farmacológico; Factores de Transcripción/genética; Amidas/síntesis química; Amidas/farmacología; Células CACO-2; Ensayos de Selección de Medicamentos Antitumorales; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Células HCT116; Humanos; Simulación del Acoplamiento Molecular; Quinolonas/química; Quinolonas/farmacología

Palabras clave

AKT; PI3Kα; anticancer; colon cancer; docking; quinolone-3-carboxamide

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factores de Transcripción / Amidas / Neoplasias Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Jordania

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