Afatinib in EGFR TKI-naïve patients with locally advanced or metastatic EGFR mutation-positive non-small cell lung cancer: Interim analysis of a Phase 3b study.

de Marinis, Filippo; Laktionov, Konstantin K; Poltoratskiy, Artem; Egorova, Inna; Hochmair, Maximilian; Passaro, Antonio; Migliorino, Maria Rita; Metro, Giulio; Gottfried, Maya; Tsoi, Daphne; Ostoros, Gyula; Rizzato, Simona; Mukhametshina, Guzel Z; Schumacher, Michael; Novello, Silvia; Dziadziuszko, Rafal; Tang, Wenbo; Clementi, Laura; Cseh, Agnieszka; Kowalski, Dariusz

de Marinis, Filippo; Laktionov, Konstantin K; Poltoratskiy, Artem; Egorova, Inna; Hochmair, Maximilian; Passaro, Antonio; Migliorino, Maria Rita; Metro, Giulio; Gottfried, Maya; Tsoi, Daphne; Ostoros, Gyula; Rizzato, Simona; Mukhametshina, Guzel Z; Schumacher, Michael; Novello, Silvia; Dziadziuszko, Rafal; Tang, Wenbo; Clementi, Laura; Cseh, Agnieszka; Kowalski, Dariusz.

Afiliación

de Marinis F; European Institute of Oncology IRCCS, Milan, Italy. Electronic address: Filippo.DeMarinis@ieo.it.
Laktionov KK; Federal State Budgetary Institution "N.N.Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), Moscow, Russia.
Poltoratskiy A; Petrov Research Institute of Oncology, St Petersburg, Russia.
Egorova I; Clinical Oncology Dispensary, St Petersburg, Russia.
Hochmair M; Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Vienna, Austria.
Passaro A; European Institute of Oncology IRCCS, Milan, Italy.
Migliorino MR; San Camillo-Forlanini Hospital, Rome, Italy.
Metro G; Santa Maria della Misericordia Hospital, Perugia, Italy.
Gottfried M; Tel Aviv University, Tel Aviv, Israel.
Tsoi D; St John of God Murdoch Hospital, Murdoch, WA, Australia.
Ostoros G; National Korányi Institute for Pulmonology, Budapest, Hungary.
Rizzato S; Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Mukhametshina GZ; Ministry of Health of the Republic of Tatarstan, Kazan, Russia.
Schumacher M; Ordensklinikum Elisabethinen, Linz, Austria.
Novello S; University of Turin, AOU San Luigi, Orbassano, Italy.
Dziadziuszko R; Medical University of Gdansk, Gdansk, Poland.
Tang W; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA.
Clementi L; Boehringer Ingelheim Italia S.p.A., Milan, Italy.
Cseh A; Boehringer Ingelheim International, Ingelheim, Germany.
Kowalski D; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Lung Cancer ; 152: 127-134, 2021 02.

Article en En | MEDLINE | ID: mdl-33387727

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Neoplasias Pulmonares; Afatinib/uso terapéutico; Anciano; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/genética; Receptores ErbB/genética; Humanos; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Mutación; Inhibidores de Proteínas Quinasas/uso terapéutico; Resultado del Tratamiento

Palabras clave

Afatinib; EGFR TKI-naïve; EGFR mutation; NSCLC; Safety

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article

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