Overlapping Effects of miR-21 Inhibition and Drugs for Idiopathic Pulmonary Fibrosis: Rationale for Repurposing Nintedanib as a Novel Treatment for Ischemia/Reperfusion Injury.
J Cardiovasc Pharmacol
; 77(3): 332-333, 2021 03 01.
Article
en En
| MEDLINE
| ID: mdl-33394826
ABSTRACT
ABSTRACT A specific anti-miR-21 has emerged as an effective treatment for ischemia/reperfusion injury in a pig model of myocardial infarction (MI), but the perspectives for clinical translation are limited. Anti-miR-21 blunts profibrotic pathways, whose excessive activation is detrimental in the post-MI setting. Repurposing antifibrotic drugs approved for other indications is a possible strategy. We compared the molecular effects of anti-miR-21 and the 2 drugs approved for idiopathic pulmonary fibrosis (nintedanib and pirfenidone) through a bioinformatic approach. We report that nintedanib and anti-miR-21 share many targets, including the proto-oncogene Rous sarcoma oncogene cellular homolog. Conversely, pirfenidone and anti-miR-21 do not have common mechanisms of action. In summary, the molecular mechanisms activated by nintedanib are partially overlapping with those elicited by anti-miR-21. Nintedanib could be evaluated in animal studies or clinical trials on MI.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piridonas
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Daño por Reperfusión Miocárdica
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MicroARNs
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Inhibidores de Proteínas Quinasas
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Fibrosis Pulmonar Idiopática
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Reposicionamiento de Medicamentos
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Infarto del Miocardio con Elevación del ST
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Indoles
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Pulmón
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia