Genetic inhibition of FABP4 attenuated endoplasmic reticulum stress and mitochondrial dysfunction in rhabdomyolysis-induced acute kidney injury.

Liu, Jing; Huang, Rongshuang; Li, Xinrui; Guo, Fan; Li, Lingzhi; Zeng, Xiaoxi; Ma, Liang; Fu, Ping

Liu, Jing; Huang, Rongshuang; Li, Xinrui; Guo, Fan; Li, Lingzhi; Zeng, Xiaoxi; Ma, Liang; Fu, Ping.

Afiliación

Liu J; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.
Huang R; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.
Li X; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.
Guo F; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.
Li L; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.
Zeng X; West China Biomedical Big Data Center, West China Hospital of Sichuan University, Chengdu 610041, China.
Ma L; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: liang_m@scu.edu.cn.
Fu P; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041, China.

Life Sci ; 268: 119023, 2021 Mar 01.

Article en En | MEDLINE | ID: mdl-33434534

Asunto(s)

Lesión Renal Aguda/etiología; Estrés del Retículo Endoplásmico/genética; Proteínas de Unión a Ácidos Grasos/genética; Mitocondrias/patología; Rabdomiólisis/patología; Factor de Transcripción Activador 6/genética; Factor de Transcripción Activador 6/metabolismo; Lesión Renal Aguda/patología; Animales; Apoptosis/genética; Proteínas de Unión a Ácidos Grasos/metabolismo; Riñón/patología; Riñón/fisiología; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Ratones Endogámicos C57BL; Ratones Noqueados; Mitocondrias/genética; Nefritis/genética; Nefritis/patología; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; eIF-2 Quinasa/genética; eIF-2 Quinasa/metabolismo

Palabras clave

Acute kidney injury; Endoplasmic reticulum stress; Fatty acid-binding protein 4; Mitochondrial dysfunction; Rhabdomyolysis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Rabdomiólisis / Proteínas de Unión a Ácidos Grasos / Lesión Renal Aguda / Estrés del Retículo Endoplásmico / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2021 Tipo del documento: Article País de afiliación: China

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