Hypoxia maintains the fenestration of liver sinusoidal endothelial cells and promotes their proliferation through the SENP1/HIF-1&#945;/VEGF signaling axis.

Qing, Zhe; Huang, Hanfei; Yang, Shikun; Lin, Jie; Zeng, Zhong; Duan, Jian; Yuan, Bo; Ming, Tingfeng

Hypoxia maintains the fenestration of liver sinusoidal endothelial cells and promotes their proliferation through the SENP1/HIF-1α/VEGF signaling axis.

Qing, Zhe; Huang, Hanfei; Yang, Shikun; Lin, Jie; Zeng, Zhong; Duan, Jian; Yuan, Bo; Ming, Tingfeng.

Afiliación

Qing Z; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
Huang H; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
Yang S; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
Lin J; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
Zeng Z; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China. Electronic address: zzong9933@163.com.
Duan J; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
Yuan B; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.
Ming T; Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China.

Biochem Biophys Res Commun ; 540: 42-50, 2021 02 12.

Article en En | MEDLINE | ID: mdl-33445109

Asunto(s)

Hipoxia de la Célula/fisiología; Proliferación Celular; Células Endoteliales/metabolismo; Hígado/citología; Transducción de Señal; Animales; Cisteína Endopeptidasas/genética; Cisteína Endopeptidasas/metabolismo; Regulación hacia Abajo; Células Endoteliales/citología; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Factor A de Crecimiento Endotelial Vascular/genética; Factor A de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

HIF-1α; Hypoxia; Liver sinusoidal endothelial cells; Sentrin/SUMO-Specific protease 1; VEGF

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Hipoxia de la Célula / Células Endoteliales / Proliferación Celular / Hígado Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article País de afiliación: China

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