The roles of microRNAs in mouse development.
Nat Rev Genet
; 22(5): 307-323, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33452500
ABSTRACT
Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns during embryonic and postnatal mouse development. The loss of all miRNAs through the deletion of critical miRNA biogenesis factors results in early lethality. The function of each miRNA stems from their cumulative negative regulation of multiple mRNA targets expressed in a particular cell type. During development, miRNAs often coordinate the timing and direction of cell fate transitions. In adults, miRNAs frequently contribute to organismal fitness through homeostatic roles in physiology. Here, we review how the recent dissection of miRNA-knockout phenotypes in mice as well as advances related to their targets, dosage, and interactions have collectively informed our understanding of the roles of miRNAs in mammalian development and adaptive responses.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
MicroARNs
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Desarrollo Embrionario
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Crecimiento
Límite:
Animals
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos