Deubiquitylating enzymes in neuronal health and disease.

Amer-Sarsour, Fatima; Kordonsky, Alina; Berdichevsky, Yevgeny; Prag, Gali; Ashkenazi, Avraham

Amer-Sarsour, Fatima; Kordonsky, Alina; Berdichevsky, Yevgeny; Prag, Gali; Ashkenazi, Avraham.

Afiliación

Amer-Sarsour F; Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Kordonsky A; School of Neurobiology, Biochemistry and Biophysics, the George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Berdichevsky Y; Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Prag G; School of Neurobiology, Biochemistry and Biophysics, the George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. prag@tauex.tau.ac.il.
Ashkenazi A; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. prag@tauex.tau.ac.il.

Cell Death Dis ; 12(1): 120, 2021 01 22.

Article en En | MEDLINE | ID: mdl-33483467

ABSTRACT

ABSTRACT

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.

Asunto(s)

Enfermedades Neurodegenerativas/genética; Ubiquitinación/genética; Humanos

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Ubiquitinación Límite: Humans Idioma: En Revista: Cell Death Dis Año: 2021 Tipo del documento: Article País de afiliación: Israel

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