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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Swidorski, Jacob J; Jenkins, Susan; Hanumegowda, Umesh; Parker, Dawn D; Beno, Brett R; Protack, Tricia; Ng, Alicia; Gupta, Anuradha; Shanmugam, Yoganand; Dicker, Ira B; Krystal, Mark; Meanwell, Nicholas A; Regueiro-Ren, Alicia.
Afiliación
  • Swidorski JJ; Department of Discovery Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address: jacob.swidorski@bms.com.
  • Jenkins S; Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Hanumegowda U; Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Parker DD; Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Beno BR; Department of Computer-Assisted Drug Design, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Protack T; Department of Virology, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Ng A; Department of Discovery Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Gupta A; Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.
  • Shanmugam Y; Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.
  • Dicker IB; Department of Virology, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Krystal M; Department of Virology, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Meanwell NA; Department of Discovery Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Regueiro-Ren A; Department of Discovery Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
Bioorg Med Chem Lett ; 36: 127823, 2021 03 15.
Article en En | MEDLINE | ID: mdl-33508465
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triterpenos / Diseño de Fármacos / VIH-1 / Fármacos Anti-VIH / Ácido Benzoico Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triterpenos / Diseño de Fármacos / VIH-1 / Fármacos Anti-VIH / Ácido Benzoico Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article