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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.
Kondrashov, Mikhail; Svensson, Samuel P S; Ström, Peter; Westermark, Andreas; Jacobson-Ingemyr, Hanna; Takano, Akihiro; Tari, Lenke; Tóth, Miklós; Cai, Minying; Hruby, Victor J; Schou, Magnus.
Afiliación
  • Kondrashov M; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77, Stockholm, Sweden.
  • Svensson SPS; Biopercept Ltd, PR2 5DB, Barnfield Way, Preston, United Kingdom.
  • Ström P; Department of Chemistry, Linkoping University, 581 83, Linkoping, Sweden.
  • Westermark A; Novandi Chemistry AB, 151 36, Södertälje, Sweden.
  • Jacobson-Ingemyr H; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77, Stockholm, Sweden.
  • Takano A; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77, Stockholm, Sweden.
  • Tari L; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77, Stockholm, Sweden.
  • Tóth M; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77, Stockholm, Sweden.
  • Cai M; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77, Stockholm, Sweden.
  • Hruby VJ; Department of Chemistry, University of Arizona, Tucson, Arizona 85721, United States.
  • Schou M; Department of Chemistry, University of Arizona, Tucson, Arizona 85721, United States.
Bioconjug Chem ; 32(3): 497-501, 2021 03 17.
Article en En | MEDLINE | ID: mdl-33576604
ABSTRACT
A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arsenicales / Melanoma Experimental / Tomografía de Emisión de Positrones / Colorantes Fluorescentes Límite: Animals Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Suecia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arsenicales / Melanoma Experimental / Tomografía de Emisión de Positrones / Colorantes Fluorescentes Límite: Animals Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Suecia