Expression of α2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss.
Curr Med Sci
; 41(1): 153-157, 2021 Feb.
Article
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| MEDLINE
| ID: mdl-33582920
ABSTRACT
K+ cycling in the cochlea is critical to maintain hearing. Many sodium-potassium pumps are proved to participate in K+ cycling, such as Na/K-ATPase. The α2-Na/K-ATPase is an important isoform of Na/K-ATPase. The expression of α2-Na/K-ATPase in the cochlea is not clear. In this study, we used C57BL/6 mice as a model of presbycusis and implemented immunohistochemistry staining and quantitative real time-PCR, and the α2-Na/K-ATPase expression pattern was confirmed in the inner ear. It was found α2-Na/K-ATPase was expressed widely in cochlea and its mRNA and protein expression was gradually reduced with aging (4-, 14-, 26- and 48-weeks old mice). We suspected that, the down-regulation of α2-Na/K-ATPase expression might be associated with the remodeling of K+ cycling, degeneration of morphological structure and decrease of hearing function in aging C57 mice. In conclusion, we speculated that the reduction of α2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Envejecimiento
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Cóclea
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ATPasa Intercambiadora de Sodio-Potasio
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Pérdida Auditiva Sensorineural
Límite:
Animals
Idioma:
En
Revista:
Curr Med Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
China