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Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.
Chen, Yu-Chi; Dinavahi, Saketh S; Feng, Qilong; Gowda, Raghavendra; Ramisetti, Srinivasa; Xia, Xinghai; LaPenna, Kyle B; Chirasani, Venkat R; Cho, Sung Hyun; Hafenstein, Susan L; Battu, Madhu Babu; Berg, Arthur; Sharma, Arun K; Kirchhausen, Tom; Dokholyan, Nikolay V; Amin, Shantu; He, Pingnian; Robertson, Gavin P.
Afiliación
  • Chen YC; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Dinavahi SS; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Feng Q; Departments of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Gowda R; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Ramisetti S; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Xia X; Departments of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • LaPenna KB; Departments of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Chirasani VR; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Cho SH; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
  • Hafenstein SL; Departments of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA.
  • Battu MB; Operon Diagnostics, Kompally, Hyderabad, 500010, India.
  • Berg A; Departments of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Sharma AK; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Kirchhausen T; Departments of Cell Biology, Harvard Medical School and Program in Cellular and Molecular Medicine at Boston Children's Hospital, MA, 02115, USA.
  • Dokholyan NV; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA; Departments of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
  • Amin S; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: sga3@psu.edu.
  • He P; Departments of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. Electronic address: pinghe@pennstatehealth.psu.edu.
  • Robertson GP; Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA; Departments of Departments of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA; Departments of Dermatology, The Pennsylvania State University College
Cancer Lett ; 506: 107-119, 2021 05 28.
Article en En | MEDLINE | ID: mdl-33600895
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cadenas Ligeras de Miosina / Células Endoteliales / Receptores de Esfingosina-1-Fosfato / Metástasis de la Neoplasia Límite: Animals / Humans Idioma: En Revista: Cancer Lett Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cadenas Ligeras de Miosina / Células Endoteliales / Receptores de Esfingosina-1-Fosfato / Metástasis de la Neoplasia Límite: Animals / Humans Idioma: En Revista: Cancer Lett Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos