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Long non-coding RNA AGAP2-AS1 promotes proliferation and metastasis in papillary thyroid cancer by miR-628-5p/KLF12 axis.
Xu, Chongwen; Shao, Yuan; Liu, Junsong; Yao, Xiaobao; Quan, Fang; Zhao, Qian; Zhao, Ruimin; Kou, Bo; Li, Honghui; Han, Peng; Wang, Xuan; Bai, Yanxia; Zheng, Zhiwei; Zhang, Shaoqiang.
Afiliación
  • Xu C; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Shao Y; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Liu J; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Yao X; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Quan F; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Zhao Q; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Zhao R; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Kou B; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Li H; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Han P; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Wang X; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Bai Y; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China.
  • Zheng Z; The Third Ward of Department of General Surgery, Rizhao People's Hospital, No.126 of Tai'an road, Shandong, 276800, Rizhao, China. zhengzhiweizw@126.com.
  • Zhang S; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi 'an Jiaotong University, NO.277 of Yanta West Road, Shaanxi, 710061, Xi'an, China. shaoqiang_zhang1@163.com.
J Bioenerg Biomembr ; 53(2): 235-245, 2021 04.
Article en En | MEDLINE | ID: mdl-33604734
ABSTRACT
Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers. However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear. Thus, in this study, we aimed to explore the role of AGAP2-AS1 in PTC. Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues. Knockdown of AGAP2-AS1 inhibited the proliferation, migration and invasion of PTC cells. In vivo experiment showed that AGAP2-AS1 knockdown inhibited the tumorigenesis of PTC. MiR-628-5p was found to act as a target miRNA of AGAP2-AS1 in PTC. The expression level of miR-628-5p in PTC tissues was negatively associated with that of AGAP2-AS1. Inhibition of miR-628-5p attenuated the effects of AGAP2-AS1 knockdown on PTC. Moreover, miR-628-5p directly bound to the 3'UTR of KLF12 and inhibited the expression of KLF12. Knockdown of KLF12 enhanced the inhibitory effects of miR-628-5p on PTC cell proliferation and metastasis. In conclusion, these findings indicated that AGAP2-AS1 exerted an oncogenic role in PTC progression and metastasis. The effects of AGAP2-AS1 might be mediated by the regulation of miR-628-5p/KLF12 axis.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / MicroARNs / ARN Largo no Codificante / Cáncer Papilar Tiroideo Límite: Animals / Humans Idioma: En Revista: J Bioenerg Biomembr Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / MicroARNs / ARN Largo no Codificante / Cáncer Papilar Tiroideo Límite: Animals / Humans Idioma: En Revista: J Bioenerg Biomembr Año: 2021 Tipo del documento: Article País de afiliación: China