MET inhibitor, capmatinib overcomes osimertinib resistance via suppression of MET/Akt/snail signaling in non-small cell lung cancer and decreased generation of cancer-associated fibroblasts.

Zhu, Kaibin; Lv, Zhonghua; Xiong, Jinsheng; Zheng, Hongshan; Zhang, Sibin; Jin, Hua; Yu, Lei; Li, Zhenzhe; Zhang, Jixing; Li, Chenlong; Liang, Peng

Zhu, Kaibin; Lv, Zhonghua; Xiong, Jinsheng; Zheng, Hongshan; Zhang, Sibin; Jin, Hua; Yu, Lei; Li, Zhenzhe; Zhang, Jixing; Li, Chenlong; Liang, Peng.

Afiliación

Zhu K; Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Lv Z; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Xiong J; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Zheng H; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Zhang S; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Jin H; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Yu L; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Li Z; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Zhang J; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Li C; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.
Liang P; Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150001, Heilongjiang, China.

Aging (Albany NY) ; 13(5): 6890-6903, 2021 02 17.

Article en En | MEDLINE | ID: mdl-33621951

Asunto(s)

Benzamidas/farmacología; Carcinoma de Pulmón de Células no Pequeñas/patología; Resistencia a Antineoplásicos/efectos de los fármacos; Imidazoles/farmacología; Neoplasias Pulmonares/patología; Transducción de Señal/efectos de los fármacos; Triazinas/farmacología; Acrilamidas/farmacología; Compuestos de Anilina/farmacología; Fibroblastos Asociados al Cáncer/metabolismo; Línea Celular Tumoral; Transición Epitelial-Mesenquimal/efectos de los fármacos; Humanos; Interleucina-1beta/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteínas Proto-Oncogénicas c-met/metabolismo; Factores de Transcripción de la Familia Snail/metabolismo

Palabras clave

MET associated signaling; cancer-associated fibroblasts (CAFs); capmatinib; non-small cell lung cancer (NSCLC); osimertinib resistance

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triazinas / Benzamidas / Transducción de Señal / Carcinoma de Pulmón de Células no Pequeñas / Resistencia a Antineoplásicos / Imidazoles / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article País de afiliación: China

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