Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as &#945;-Phenyl-<i>N-tert</i>-butylnitrone Analogues in In Vitro Ischemia Models.

Chamorro, Beatriz; García-Vieira, David; Diez-Iriepa, Daniel; Garagarza, Estíbaliz; Chioua, Mourad; Hadjipavlou-Litina, Dimitra; López-Muñoz, Francisco; Marco-Contelles, José; Oset-Gasque, María Jesús

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models.

Chamorro, Beatriz; García-Vieira, David; Diez-Iriepa, Daniel; Garagarza, Estíbaliz; Chioua, Mourad; Hadjipavlou-Litina, Dimitra; López-Muñoz, Francisco; Marco-Contelles, José; Oset-Gasque, María Jesús.

Afiliación

Chamorro B; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.
García-Vieira D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Diez-Iriepa D; Faculty of Health, Camilo José Cela University of Madrid (UCJC), Castillo de Alarcón 49, 28692 Villanueva de la Cañada, Spain.
Garagarza E; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Chioua M; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Hadjipavlou-Litina D; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, 28805 Alcalá de Henares, Spain.
López-Muñoz F; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.
Marco-Contelles J; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Oset-Gasque MJ; Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Molecules ; 26(4)2021 Feb 20.

Article en En | MEDLINE | ID: mdl-33672652

Asunto(s)

Antioxidantes/farmacología; Óxidos N-Cíclicos/farmacología; Inhibidores de la Lipooxigenasa/farmacología; Lipooxigenasa/metabolismo; Fármacos Neuroprotectores/farmacología; Antioxidantes/síntesis química; Antioxidantes/química; Óxidos N-Cíclicos/síntesis química; Óxidos N-Cíclicos/química; Humanos; Radical Hidroxilo/antagonistas & inhibidores; Peroxidación de Lípido/efectos de los fármacos; Inhibidores de la Lipooxigenasa/síntesis química; Inhibidores de la Lipooxigenasa/química; Estructura Molecular; Fármacos Neuroprotectores/síntesis química; Fármacos Neuroprotectores/química; Células Tumorales Cultivadas

Palabras clave

1,1'-biphenyl nitrones; antioxidants; free radical scavengers; neuroprotection; oligomycin A/rotenone; oxygen-glucose-deprivation; synthesis; α-phenyl-N-tert-butylnitrone

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de la Lipooxigenasa / Lipooxigenasa / Fármacos Neuroprotectores / Óxidos N-Cíclicos / Antioxidantes Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: España

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