Methylation of ERß 5'-untranslated region attenuates its inhibitory effect on ER&#945; gene transcription and promotes the initiation and progression of papillary thyroid cancer.

Xu, Lin-Wan; Gou, Xi; Yang, Jun-Yan; Jiang, Rong; Jiang, Xue; Chen, George G; Liu, Zhi-Min

Methylation of ERß 5'-untranslated region attenuates its inhibitory effect on ERα gene transcription and promotes the initiation and progression of papillary thyroid cancer.

Xu, Lin-Wan; Gou, Xi; Yang, Jun-Yan; Jiang, Rong; Jiang, Xue; Chen, George G; Liu, Zhi-Min.

Afiliación

Xu LW; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Gou X; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Yang JY; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Jiang R; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Jiang X; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Chen GG; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Liu ZM; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.

FASEB J ; 35(4): e21516, 2021 04.

Article en En | MEDLINE | ID: mdl-33710697

Asunto(s)

Receptor alfa de Estrógeno/genética; Regulación Neoplásica de la Expresión Génica/genética; Cáncer Papilar Tiroideo/genética; Neoplasias de la Tiroides/genética; Línea Celular Tumoral; Regulación hacia Abajo; Receptor beta de Estrógeno/genética; Receptor beta de Estrógeno/metabolismo; Humanos; Receptores de Estrógenos/metabolismo; Regulación hacia Arriba

Palabras clave

5'-untranslated region; ERα mRNA (A-1); ERß mRNA (0N-1)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Regulación Neoplásica de la Expresión Génica / Receptor alfa de Estrógeno / Cáncer Papilar Tiroideo Límite: Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China

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