Nanoparticle-Based Delivery to Treat Spinal Cord Injury-a Mini-review.
AAPS PharmSciTech
; 22(3): 101, 2021 Mar 12.
Article
en En
| MEDLINE
| ID: mdl-33712968
ABSTRACT
There is an increasing need to develop improved and non-invasive strategies to treat spinal cord injury (SCI). Nanoparticles (NPs) are an enabling technology to improve drug delivery, modulate inflammatory responses, and restore functional responses following SCI. However, the complex pathophysiology associated with SCI presents several distinct challenges that must be overcome for sufficient NP drug delivery to the spinal cord. The objective of this mini-review is to highlight the physiological challenges and cell types available for modulation and discuss several promising advancements using NPs to improve SCI treatment. We will focus our discussion on recent innovative approaches in NP drug delivery and how the implementation of multifactorial approaches to address the proinflammatory and complex immune dysfunction in SCI offers significant potential to improve outcomes in SCI.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Sistemas de Liberación de Medicamentos
/
Nanopartículas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
AAPS PharmSciTech
Asunto de la revista:
FARMACOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos