The first copper(I) complex of anthrahydrazone with potential ROS scavenging activity showed significant in vitro anticancer activity by inducing apoptosis and autophagy.

Liu, Rui-Xue; Luo, Ru-Yi; Tang, Meng-Ting; Liu, Yan-Cheng; Chen, Zhen-Feng; Liang, Hong

Liu, Rui-Xue; Luo, Ru-Yi; Tang, Meng-Ting; Liu, Yan-Cheng; Chen, Zhen-Feng; Liang, Hong.

Afiliación

Liu RX; School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China.
Luo RY; School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China.
Tang MT; School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China.
Liu YC; School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China. Electronic address: ycliu@gxnu.edu.cn.
Chen ZF; School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China.
Liang H; School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China. Electronic address: hliang@gxnu.edu.cn.

J Inorg Biochem ; 218: 111390, 2021 05.

Article en En | MEDLINE | ID: mdl-33721719

Asunto(s)

Antracenos/química; Antineoplásicos/farmacología; Complejos de Coordinación/farmacología; Cobre/química; Depuradores de Radicales Libres/farmacología; Neoplasias/tratamiento farmacológico; Especies Reactivas de Oxígeno/metabolismo; Antineoplásicos/química; Apoptosis; Autofagia; Puntos de Control del Ciclo Celular; Muerte Celular; Complejos de Coordinación/química; Cristalografía por Rayos X; Depuradores de Radicales Libres/química; Humanos; Técnicas In Vitro; Mitocondrias/efectos de los fármacos; Mitocondrias/patología; Modelos Moleculares; Estructura Molecular; Neoplasias/patología; Células Tumorales Cultivadas

Palabras clave

Anthrahydrazone; Anticancer activity; Autophagy; Cell apoptosis; Reactive oxygen species; Transition metal complex

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Depuradores de Radicales Libres / Especies Reactivas de Oxígeno / Cobre / Complejos de Coordinación / Antracenos / Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2021 Tipo del documento: Article

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