Effect of piroxicam administration in infertile women undergoing assisted reproductive technologies: A systematic review and meta-analysis.
Gynecol Endocrinol
; 37(9): 785-791, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-33733994
ABSTRACT
OBJECTIVE:
To evaluate piroxicam effect on different pregnancy outcomes among infertile women undergoing assisted reproductive technologies (ART).METHODS:
We searched for the available randomized clinical trials (RCTs) in four different databases during January 2021 that compared piroxicam (intervention group) to placebo/no treatment (control group) in infertile women performing ART. We extracted the available data from included studies and pooled them in a meta-analysis model using RevMan software. We pooled the dichotomous data as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Our outcomes were rates of clinical pregnancy, ongoing pregnancy, miscarriage, and any adverse events.RESULTS:
Seven RCTs met our inclusion criteria with a total number of 1226 patients. Piroxicam was linked to a significant increase in clinical pregnancy rate compared to control group (RR = 1.30, 95% CI [1.09, 1.55], p = .003). However, we did not report any significant difference between both groups in ongoing pregnancy rate (RR = 1.27, 95% CI [0.72, 2.24], p = .41). In addition, the rates of miscarriage and adverse events were not different among both groups.CONCLUSIONS:
Piroxicam administration increases the clinical pregnancy rate among infertile women. However, piroxicam does not affect miscarriage and ongoing pregnancy rates.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piroxicam
/
Antiinflamatorios no Esteroideos
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Técnicas Reproductivas Asistidas
/
Infertilidad Femenina
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Límite:
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Gynecol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Egipto