Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
Biochem Pharmacol
; 37(9): 1673-7, 1988 May 01.
Article
en En
| MEDLINE
| ID: mdl-3377829
Catalytic activities of two amine N-methyltransferases were documented for the following azaheterocycles: isomeric phenyl- and bispyridyls; 2-, 3- and 4-mono-substituted pyridines; and a miscellaneous group of azaheterocycles that included mono- and diazabenzenes and mono- and diazanaphthalenes. The broad substrate specificities of the two amine N-methyltransferases for primary and secondary amines are here extended to a large number of aromatic azaheterocycles in which N-methylation results in the formation of quaternary ammonium metabolites. Pyridine was the best substrate for both enzymes. Substitution in the ring at the 2-position sterically hindered methylation of the pyridyl nitrogen; 2-phenylpyridine and 2,2'-bispyridyl were not substrates.
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Bases de datos:
MEDLINE
Asunto principal:
Compuestos Aza
/
Aminas
/
Compuestos Heterocíclicos
/
Metiltransferasas
Límite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Año:
1988
Tipo del documento:
Article