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Copper-Photocatalyzed Hydroboration of Alkynes and Alkenes.
Zhong, Mingbing; Gagné, Yohann; Hope, Taylor O; Pannecoucke, Xavier; Frenette, Mathieu; Jubault, Philippe; Poisson, Thomas.
Afiliación
  • Zhong M; Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
  • Gagné Y; Département de Chimie, Université du Québec à Montréal, Case postal 8888, Succursale Centre-Ville, Montréal, Québec, H3C 3P8, Canada.
  • Hope TO; Département de Chimie, Université du Québec à Montréal, Case postal 8888, Succursale Centre-Ville, Montréal, Québec, H3C 3P8, Canada.
  • Pannecoucke X; Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
  • Frenette M; Département de Chimie, Université du Québec à Montréal, Case postal 8888, Succursale Centre-Ville, Montréal, Québec, H3C 3P8, Canada.
  • Jubault P; Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
  • Poisson T; Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Angew Chem Int Ed Engl ; 60(26): 14498-14503, 2021 Jun 21.
Article en En | MEDLINE | ID: mdl-33780588
The photocatalytic hydroboration of alkenes and alkynes is reported. The use of newly-designed copper photocatalysts with B2 Pin2 permits the formation a boryl radical, which is used for hydroboration of a large panel of alkenes and alkynes. The hydroborated products were isolated in high yields, with excellent diastereoselectivities and a high functional group tolerance under mild conditions. The hydroboration reactions were developed under continuous flow conditions to demonstrate their synthetic utility. The reaction mechanism was studied and suggested an oxidation reaction between an in situ formed borate and the Cu-photocatalyst in its excited state for the boryl radical formation.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Francia