Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis.
Reproduction
; 161(5): 593-602, 2021 04 20.
Article
en En
| MEDLINE
| ID: mdl-33784244
ABSTRACT
The epididymis is an androgen-responsive organ, whose structure and functions are modulated by the coordination between androgen and epididymal cues. Highly regulated molecular interaction within the epididymis is required to support viable sperm development necessary for subsequent fertilization. In the present study, we extended our earlier findings on a promising epididymal protein, quiescin sulfhydryl oxidase 2 (QSOX2), and demonstrated a positive correlation between testosterone and QSOX2 protein synthesis through the use of loss- and restore-of-function animal models. Moreover, based on transcriptomic analyses and 2D culture system, we determined that an additional polarized effect of glutamate is indispensable for the regulatory action of testosterone on QSOX2 synthesis. In conclusion, we propose noncanonical testosterone signaling supports epididymal QSOX2 protein synthesis, providing a novel perspective on the regulation of sperm maturation within the epididymis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Maduración del Esperma
/
Testosterona
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Regulación de la Expresión Génica
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Ácido Glutámico
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Epidídimo
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Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro
/
Glutamina
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Reproduction
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Taiwán