DECO: a framework for jointly analyzing de novo and rare case/control variants, and biological pathways.

Nguyen, Tan-Hoang; He, Xin; Brown, Ruth C; Webb, Bradley T; Kendler, Kenneth S; Vladimirov, Vladimir I; Riley, Brien P; Bacanu, Silviu-Alin

Nguyen, Tan-Hoang; He, Xin; Brown, Ruth C; Webb, Bradley T; Kendler, Kenneth S; Vladimirov, Vladimir I; Riley, Brien P; Bacanu, Silviu-Alin.

Afiliación

Nguyen TH; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
He X; The Department of Human Genetics, University of Chicago, IL 60637, USA; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637, USA.
Brown RC; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Webb BT; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Kendler KS; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Vladimirov VI; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry & Behavioral Sciences, College of Medicine, Texas A&M University, College Station, TX, USA; and the Lieber Institute for Brain D
Riley BP; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Bacanu SA; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.

Brief Bioinform ; 22(5)2021 09 02.

Article en En | MEDLINE | ID: mdl-33791774

Asunto(s)

Predisposición Genética a la Enfermedad/genética; Mutación; Trastornos del Neurodesarrollo/genética; Esquizofrenia/genética; Biología de Sistemas/métodos; Estudios de Casos y Controles; Simulación por Computador; Análisis Mutacional de ADN/métodos; Humanos; Modelos Estadísticos; Mapeo de Interacción de Proteínas/métodos; Mapas de Interacción de Proteínas/genética

Palabras clave

de novo mutation; integrative analysis; neurodevelopmental disorder; neuropsychiatric disorder

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esquizofrenia / Predisposición Genética a la Enfermedad / Biología de Sistemas / Trastornos del Neurodesarrollo / Mutación Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Brief Bioinform Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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