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Extracellular vesicles: Critical players during cell migration.
Sung, Bong Hwan; Parent, Carole A; Weaver, Alissa M.
Afiliación
  • Sung BH; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 Medical Center Dr, Nashville, TN 37232, USA.
  • Parent CA; Department of Pharmacology, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA.
  • Weaver AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 Medical Center Dr, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA. Electronic address: alissa.weaver@vanderbilt.edu.
Dev Cell ; 56(13): 1861-1874, 2021 07 12.
Article en En | MEDLINE | ID: mdl-33811804
ABSTRACT
Cell migration is essential for the development and maintenance of multicellular organisms, contributing to embryogenesis, wound healing, immune response, and other critical processes. It is also involved in the pathogenesis of many diseases, including immune deficiency disorders and cancer metastasis. Recently, extracellular vesicles (EVs) have been shown to play important roles in cell migration. Here, we review recent studies describing the functions of EVs in multiple aspects of cell motility, including directional sensing, cell adhesion, extracellular matrix (ECM) degradation, and leader-follower behavior. We also discuss the role of EVs in migration during development and disease and the utility of imaging tools for studying the role of EVs in cell migration.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Adhesión Celular / Movimiento Celular / Matriz Extracelular / Vesículas Extracelulares Límite: Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Adhesión Celular / Movimiento Celular / Matriz Extracelular / Vesículas Extracelulares Límite: Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos