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A genetically encoded sensor for measuring serotonin dynamics.
Wan, Jinxia; Peng, Wanling; Li, Xuelin; Qian, Tongrui; Song, Kun; Zeng, Jianzhi; Deng, Fei; Hao, Suyu; Feng, Jiesi; Zhang, Peng; Zhang, Yajun; Zou, Jing; Pan, Sunlei; Shin, Mimi; Venton, B Jill; Zhu, J Julius; Jing, Miao; Xu, Min; Li, Yulong.
Afiliación
  • Wan J; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Peng W; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Li X; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Qian T; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Song K; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Zeng J; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Deng F; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Hao S; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Feng J; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Zhang P; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Zhang Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Zou J; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Pan S; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Shin M; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Venton BJ; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Zhu JJ; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
  • Jing M; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • Xu M; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Li Y; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Nat Neurosci ; 24(5): 746-752, 2021 05.
Article en En | MEDLINE | ID: mdl-33821000
ABSTRACT
Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the release of 5-HT, we developed a genetically encoded G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB5-HT) sensor with high sensitivity, high selectivity, subsecond kinetics and subcellular resolution. GRAB5-HT detects 5-HT release in multiple physiological and pathological conditions in both flies and mice and provides new insights into the dynamics and mechanisms of 5-HT signaling.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Serotonina / Receptores Acoplados a Proteínas G / Neuronas Serotoninérgicas / Neuronas Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Serotonina / Receptores Acoplados a Proteínas G / Neuronas Serotoninérgicas / Neuronas Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China