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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.
Hipp, Joerg F; Knoflach, Frederic; Comley, Robert; Ballard, Theresa M; Honer, Michael; Trube, Gerhard; Gasser, Rodolfo; Prinssen, Eric; Wallace, Tanya L; Rothfuss, Andreas; Knust, Henner; Lennon-Chrimes, Sian; Derks, Michael; Bentley, Darren; Squassante, Lisa; Nave, Stephane; Nöldeke, Jana; Wandel, Christoph; Thomas, Andrew W; Hernandez, Maria-Clemencia.
Afiliación
  • Hipp JF; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Knoflach F; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Comley R; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Ballard TM; AbbVie Inc, North Chicago, IL, USA.
  • Honer M; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Trube G; Galwyn (UK) Ltd, Dartmouth, Devon, UK.
  • Gasser R; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Prinssen E; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Wallace TL; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Rothfuss A; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Knust H; CNS Research, Roche Bioscience, Palo Alto, USA.
  • Lennon-Chrimes S; BlackThorn Therapeutics, 780 Brannan Street, San Francisco, CA, 94103, USA.
  • Derks M; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Bentley D; Small Molecule Research, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Squassante L; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK.
  • Nave S; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK.
  • Nöldeke J; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK.
  • Wandel C; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Thomas AW; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Hernandez MC; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Sci Rep ; 11(1): 7700, 2021 04 08.
Article en En | MEDLINE | ID: mdl-33833333
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de GABA-A / Agonistas de Receptores de GABA-A Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de GABA-A / Agonistas de Receptores de GABA-A Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Suiza